1890 Coca and its Therapeutic Application by Angelo Mariani

— 42-

According to Dr.Colombe (1),Coca is a potent factor in the treatment of syphilis.(2) "It is demonstrated that potassium iodide and potassium chlorate undergo double decomposition in the system,and thus interfere with each other's action. Coca, substituted for the chlorate under such.circumstances, would not be open to the same objec tion. It would find its application, therefore, when the mixed treatment is found necessary."

DISEASES OF THE THROAT, PHARYNX AND THE LARYNX.

As regards the angincs, the acute inflammations of the larynx and pharynx,we might repeat what has been said about inflammations of the mouth. In particular,the pain, so violent in certain migincs, calls for this method of treat ment. The same is true of the dysphagia which accompa nies them. Charles Fauvel first recognized the virtues of Coca in the tingling of follicular angina and the laryngeal pains of tuberculous subjects. In those cases he specifies Mari- ani's extract of Coca leaves in preference to solutions of Cocaine, which sometimes give rise to symptoms of poisoning. Dr. Rouquette(3) relates a case of tubercular laryngitis in which symptoms of poisoning showed themselves as early as the third day; the parts had been painted twice a day with a five-per-cent solution of Cocaine. Dr. Paul Legendre has quite recently mentioned anew the danger that may result from a too free use of Co-

(1) Th^se de Paris^ 1885. (2) Btimstead and Taylor on VenerealDiseases, (3) ThiHrapeutique contemporaine^ January, 1888.